|Ghosts of the Sargasso|
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|Main Series||The Venture Bros.|
|Original Airdate||September 11, 2004|
|Executive producer(s)||Jackson Publick|
Steven S. H. Yoon
|Voices of||James Urbaniak|
|Opening theme||"No Vacancy" by J.G. Thirlwell|
|Ending theme||"Tuff" by J.G. Thirlwell|
|Previous Episode||Eeney, Meeney, Miney...Magic!|
|Next Episode||Ice Station-Impossible!|
- James Urbaniak as Dr. Rusty Venture, Major Tom
- Michael Sinterniklaas as Dean Venture
- Patrick Warburton as Brock Samson
- Chris McCulloch as Hank Venture, The Pirate Captain, The Action Man, Ghost Pirate #1, Ghost Pirate #3, Major Tom's Ghost
- Steven Rattazzi as Dr. Byron Orpheus
- Paul Boocock as Jonas Venture, Sr.
- Doc Hammer as Ghost Pirate #2
- Lisa Hammer as Jeanie Tom
- Soul-Bot as H.E.L.P.eR.