Homestar Runner is an online Flash animated web series created by Mike and Matt Chapman, also known as The Brothers Chaps, originally beginning life as a picture book before becoming a web series in 2000.
In the Robot Chicken episode "Hey I Found Another Sock," the characters appear in a sketch and get gunned down by the FBI. After which they bring them back to headquarters and intterogate them.
The sketch marks one of few times that the charactets being parodied aren't done so in the show's usual stop-motion animated style. However, the FBI officials are.